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Vincent Joseph McHugh was the eldest child of Michael Joseph McHugh (1868-1946), a printer and an amateur painter, and his wife, Mary Esther, née Young (1874-1916), who were married on 5 August 1903. The family was of Irish- and Scotch-American stock. Vincent had two brothers and one sister.
Vincent was raised Roman Catholic and educated at La Salle Academy and Providence College, where he spent one year. He later noted that he was "forced out of the latter institution for reasons not unlike Shelley's in similar circumstances. I had been very reluctant to bring up my non-religious views." He worked at odd jobs but felt that the four years he spent as a public library messenger had probably decided his taste. From the age of seventeen, he wrote book reviews for the Double Dealer of New Orleans. He began a first novel at age twenty.
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Two of McHugh's novels are fantastical in nature. Caleb Catlum's America (New York: Stackpole Sons, 1936) is a mix of tall tales and satire. The eponymous folk hero Caleb Catlum, who was born in 1798, tells the story of his first one hundred years and his friendships with some well-known historical figures, like Ben Franklin, Tom Jefferson, Huck Finn, Sam Clemens, Dan'l Boone, Buffalo Bill, and Uncle Remus. It was mostly well-received and quickly went into multiple printings.
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Through the 1930s and 1950s McHugh had a large number of varied jobs. He was editor-in-chief of the Federal Writers' Project in New York City, and oversaw the New York Panorama and New York City Guide, both published in 1939. For some years he was a staff writer at the New Yorker. He taught a course on the "Technique of the Novel" at New York University, and worked as a writer-director of some propaganda films for the Office of War Information. In 1944 he moved to California and became a contract writer for Paramount Pictures, leaving after the minimum ten weeks even though he was offered a renewal. He spent several months in the South Pacific as a merchant marine correspondent (this experience provided the basis for his novel The Victory, and the related 1953 paperback collection of short stories, Edge of the World), before returning to New York. From 1948 to 1952 he lectured and taught at various writer's conferences and colleges in New Mexico, Colorado, Missouri, and New Hampshire. His nonfiction book Primer of the Novel was published in 1950, and at this time he contributed a number of sea stories to Argosy. He moved to San Francisco in December 1952.
He had divorced his first wife in 1945, and thereafter married at least two more times. One marriage (c. 1948) was to Adeliza Sorenson (1912-2003), of St. George, Utah, an artist known familiarly as Addie. The marriage also ended in divorce, and McHugh was married again, on 5 February 1965, to Patricia A. Tool (b. 1927) in San Francisco. They settled in Sacramento.
McHugh's last three books were small press translations, with C.H. Kwock, from the Chinese: Why I Live on the Mountain: 30 Chinese Poems from the Great Dynasties (1958), The Lady and the Hermit: 30 Chinese Poems (1962), and Old Friend from Far Away: 150 Chinese Poems from the Great Dynasties (1980).
McHugh died of respiratory complications at a hospital in Sacramento. His body was cremated.